Raising the
Gold Standard in Integrated Interbody™

Only Centinel Spine merges the established advantages of titanium with the subsidence resistance and visualization benefits of PEEK and the proven clinical success of STALIF® technology to provide spine surgeons with titanium-coated, Integrated Interbody™ systems.

Not All Titanium Coatings are Created Equal.

Ti-ACTIVE™ is engineered with over 15 years of science and experience to produce an optimized surface topography enabling cellular proliferation.1, 2, 3, 4

Optimized Surface Topography.1

The Ti-ACTIVE™ coating provides a three-dimensional texturized surface that is microporous with hydrophilic properties, to facilitate human mesenchymal stem cell (hMSC) attachment and proliferation as demonstrated in pre-clinical studies with representative PEEK coupons with Ti-ACTIVE coating.2

During manufacturing, commercially pure titanium (CP Ti) is applied to the PEEK cage by a plasma spray to create our Ti-ACTIVE devices. The unique CP Ti coating system utilizes a robotic applicator, enabling the creation of a high-quality, reproducible titanium coating. Ti-ACTIVE was tested for mechanical integrity and the results exceeded the FDA requirements for shear and tensile strength for metallic spray coatings. 

Surface Topography Comparison

Cell migration of cultured cells studied by scanning electron microscopy (SEM). The PEEK device (left) shows the absence of any cell attachment to the surface. The Ti-ACTIVE™-coated device (right) shows cell attachment and cell migration seen by cytoplasmic expansions of the cultured cells, as highlighted in purple.
STALIF C-Ti™ Device with SEM-Magnified Surface Topography.
Bony Endplate Contact and Enhanced Stability.5, 6

The Ti-ACTIVE coating increases the surface area of the No-Profile®, Stand-Alone, Integrated Interbody™ device that is in contact with the bony endplates at the fusion site.

The texturized, titanium coating is 20 times rougher than an uncoated PEEK implant.6 This texturized topography increases the coefficient of friction at the fusion site providing for enhanced stability upon implantation.5

One-and-Only STALIF® Combination.

Ti-ACTIVE is the only titanium coating to be combined with the STALIF No-Profile, Stand-Alone, Integrated Interbody technology.

Only Ti-ACTIVE-coated STALIF devices provide a three-point stability advantage with increased insertion friction, increased surface contact area with bony endplates and compressive fixation at the graft site through a lag screw design.2, 5 

The Lag Effect

Compressive lag fixation ensures biomechanical stability and provides secure graft-endplate contact. Lag screws reduce the vertebral bodies onto the PEEK Cage creating graft / endplate surface compression to provide the best opportunity for fusion.

Radiolucent Advantage

Ti-ACTIVE™ devices maintain the radiolucent advantage of PEEK, making it easier to assess post-operative development of fusion mass during follow-up. Images show radiographs of STALIF C-Ti™ (left group) and MIDLINE II-Ti™ (right group) in Anterior / Posterior view (left) and Lateral view (right).
For More Information, Please Explore the Following:
1 Lebl DR. Mechanical performance of cervical TDRs in vivo. Spine (Phila, PA 1976) 2012 Dec 15; 37(26): 2151-60.
2 References on File/Internal Reports; Centinel Spine, Inc. LBL 073 Rev 1.
3 Centinel Spine Report VAL-2014-009.
4 Centinel Spine Report CD12-03-07-038.
5 Centinel Spine Report VAL-2014-010.
6 Centinel Spine Report VAL-2013-043.

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Hear from a STALIF Patient:

Without a doubt I would recommend the surgery that I had because I have my life back.

- Renee, TX