Gold Standard in Integrated Interbody™
Only Centinel Spine merges the established advantages of titanium with the subsidence resistance and
visualization benefits of PEEK and the proven clinical success of STALIF® technology to provide spine surgeons with titanium, endplate-facing,
Integrated Interbody™ systems.
Not All Titanium Coatings are Created Equal.
Ti-ACTIVE™ is engineered with over 15 years of science and experience to produce an optimized surface topography enabling cellular proliferation.1, 2, 3, 4
Ti-ACTIVE™ is designed and manufactured with a highly refined process with rigorous inspection. In the manufacturing process, there are specific areas
of the implant that are masked in order to ensure that the surface maintains certain thickness and tensile strength characteristics.
The re-surfacing process is conducted by a robotic arm in a vacuum environment with controlled temperature and pressure for better control over
the quality and reproducibility of the surface.
Above: Uncoated areas ensure consistent coverage and surface integrity
Above: Actual photomicrograph of Ti-ACTIVE™ coupon
Finally, the PEEK is heated to make it more receptive to the titanium resurfacing, and provide
the optimal environment for interdigitation of the titanium into the PEEK.
To ensure the final surface meets minimum required standards, 100% of all Ti-ACTIVE™ lots are inspected to verify surface thickness,
tensile strength, and porosity versus validation requirements.
When this surface was tested using the FDA ‘metal on metal’ testing protocols, it significantly exceeded FDA standards for shear and tensile bond strength.
All Centinel devices using Ti-ACTIVE™ are sterile-packed, avoiding the cyclic shrinking/stretching rates that may cause differing materials to separate
as they are heated and cooled during the sterilization processes.
as Compared to PEEK5
of Human Mesenchymal Stem Cells (hMSCs) Compared to Coarser Ti-coated PEEK Surfaces6
24-Hour hMSCs Count was 20x Greater Compared to Other Titanium Surfaces6
One-and-Only STALIF® Combination.
Ti-ACTIVE is the only titanium coating to be combined with the STALIF No-Profile, Stand-Alone, Integrated Interbody technology.
Only Ti-ACTIVE-coated STALIF devices provide a three-point stability advantage with increased insertion friction,
increased surface contact area with bony endplates and compressive fixation at the graft site through a lag screw design.2, 7
The Lag Effect
Compressive lag fixation ensures biomechanical stability and provides secure graft-endplate contact. Lag screws reduce the
vertebral bodies onto the PEEK Cage creating graft / endplate surface compression to provide the best opportunity for fusion.
Ti-ACTIVE™ devices maintain the radiolucent advantage of PEEK, making it easier to assess post-operative development of
fusion mass during follow-up. Images show radiographs of STALIF C-Ti™ (left group) and MIDLINE II-Ti™ (right group) in
Anterior / Posterior view (left) and Lateral view (right).
For More Information, Please Explore the Following:
1 Lebl DR. Mechanical performance of cervical TDRs in vivo. Spine (Phila, PA 1976) 2012 Dec 15; 37(26): 2151-60.
2 References on File/Internal Reports; Centinel Spine, Inc. LBL 073 Rev 1.
3 Centinel Spine Report VAL-2014-009.
4 Centinel Spine Report CD12-03-07-038.
5 Centinel Spine Report VAL-2013-035.
6 Yoon BJ1, et al. Optimizing surface characteristics for cell adhesion and proliferation on titanium plasma spray coatings on PEEK. Spine J. 2016 May 27. pii: S1529-9430(16)30203-0. doi: 10.1016/j.spinee.2016.05.017. [Epub ahead of print].
7 Centinel Spine Report VAL-2014-010.